Effects of annual influenza vaccination on winter mortality in elderly people with chronic pulmonary disease.
Identifieur interne : 000545 ( Main/Exploration ); précédent : 000544; suivant : 000546Effects of annual influenza vaccination on winter mortality in elderly people with chronic pulmonary disease.
Auteurs : A. Vila-C Rcoles [Espagne] ; O. Ochoa ; C. De Diego ; A. Valdivieso ; I. Herreros ; F. Bobé ; M. Alvarez ; M. Juárez ; I. Guinea ; X. Ansa ; N. SaúnSource :
- International journal of clinical practice [ 1368-5031 ] ; 2008.
Descripteurs français
- KwdFr :
- Broncho-pneumopathie chronique obstructive (mortalité), Calendrier vaccinal (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (prévention et contrôle), Humains (MeSH), Mâle (MeSH), Méthodes épidémiologiques (MeSH), Saisons (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccins antigrippaux (MeSH).
- MESH :
- mortalité : Broncho-pneumopathie chronique obstructive.
- prévention et contrôle : Grippe humaine.
- épidémiologie : Espagne.
- Calendrier vaccinal, Femelle, Humains, Mâle, Méthodes épidémiologiques, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Vaccins antigrippaux.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- chemical : Influenza Vaccines.
- geographic , epidemiology : Spain.
- mortality : Pulmonary Disease, Chronic Obstructive.
- prevention & control : Influenza, Human.
- Aged, Aged, 80 and over, Epidemiologic Methods, Female, Humans, Immunization Schedule, Male, Seasons.
Abstract
BACKGROUND
Although there is a general agreement for the recommendation of the influenza vaccine to persons with chronic obstructive pulmonary disease (COPD), the magnitude of clinical effectiveness and benefit from the annual vaccination is controversial. We assessed the effects of annual influenza vaccination on winter mortality in older adults with COPD.
METHODS
This prospective cohort study included 1298 Spanish community-dwelling individuals aged 65 years or older with a diagnosis of COPD followed from 1 January 2002 to 30 April 2005. The primary outcome was all-cause death during influenza periods (January-April). Multivariable Cox proportional hazard models adjusted by age, sex and comorbidity were used to evaluate vaccine effectiveness.
RESULTS
Influenza vaccination was associated with a non-statistically significant 16% reduction in winter mortality among vaccinated COPD patients [unadjusted hazard ratio (HR): 0.84; 95% confidence interval (CI): 0.60-1.17]. Multivariable analysis showed that there was an insignificant trend towards a reduced mortality in the vaccinated group considering overall influenza periods 2002-2005 (adjusted HR: 0.76; 95% CI: 0.52-1.06; p=0.098). We estimated that, in the total COPD population, one death was prevented for every 187 annual vaccinations (95% CI: 62 to infinity).
CONCLUSIONS
Our data suggest benefit from the influenza vaccination and support an annual vaccination strategy for elderly COPD patients.
DOI: 10.1111/j.1742-1241.2007.01414.x
PubMed: 17573840
Affiliations:
Links toward previous steps (curation, corpus...)
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De Diego</name></author><author><name sortKey="Valdivieso, A" sort="Valdivieso, A" uniqKey="Valdivieso A" first="A" last="Valdivieso">A. Valdivieso</name></author><author><name sortKey="Herreros, I" sort="Herreros, I" uniqKey="Herreros I" first="I" last="Herreros">I. Herreros</name></author><author><name sortKey="Bobe, F" sort="Bobe, F" uniqKey="Bobe F" first="F" last="Bobé">F. Bobé</name></author><author><name sortKey="Alvarez, M" sort="Alvarez, M" uniqKey="Alvarez M" first="M" last="Alvarez">M. Alvarez</name></author><author><name sortKey="Juarez, M" sort="Juarez, M" uniqKey="Juarez M" first="M" last="Juárez">M. Juárez</name></author><author><name sortKey="Guinea, I" sort="Guinea, I" uniqKey="Guinea I" first="I" last="Guinea">I. Guinea</name></author><author><name sortKey="Ansa, X" sort="Ansa, X" uniqKey="Ansa X" first="X" last="Ansa">X. Ansa</name></author><author><name sortKey="Saun, N" sort="Saun, N" uniqKey="Saun N" first="N" last="Saún">N. 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Vila-C Rcoles</name><affiliation wicri:level="1"><nlm:affiliation>Primary Care Service of Tarragona-Valls, Institut Català de la Salut, Tarragona, Spain. avila.tarte.ics@gencat.net</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Primary Care Service of Tarragona-Valls, Institut Català de la Salut, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Ochoa, O" sort="Ochoa, O" uniqKey="Ochoa O" first="O" last="Ochoa">O. Ochoa</name></author><author><name sortKey="De Diego, C" sort="De Diego, C" uniqKey="De Diego C" first="C" last="De Diego">C. De Diego</name></author><author><name sortKey="Valdivieso, A" sort="Valdivieso, A" uniqKey="Valdivieso A" first="A" last="Valdivieso">A. Valdivieso</name></author><author><name sortKey="Herreros, I" sort="Herreros, I" uniqKey="Herreros I" first="I" last="Herreros">I. Herreros</name></author><author><name sortKey="Bobe, F" sort="Bobe, F" uniqKey="Bobe F" first="F" last="Bobé">F. Bobé</name></author><author><name sortKey="Alvarez, M" sort="Alvarez, M" uniqKey="Alvarez M" first="M" last="Alvarez">M. Alvarez</name></author><author><name sortKey="Juarez, M" sort="Juarez, M" uniqKey="Juarez M" first="M" last="Juárez">M. Juárez</name></author><author><name sortKey="Guinea, I" sort="Guinea, I" uniqKey="Guinea I" first="I" last="Guinea">I. Guinea</name></author><author><name sortKey="Ansa, X" sort="Ansa, X" uniqKey="Ansa X" first="X" last="Ansa">X. Ansa</name></author><author><name sortKey="Saun, N" sort="Saun, N" uniqKey="Saun N" first="N" last="Saún">N. Saún</name></author></analytic><series><title level="j">International journal of clinical practice</title><idno type="ISSN">1368-5031</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Epidemiologic Methods (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunization Schedule (MeSH)</term><term>Influenza Vaccines (MeSH)</term><term>Influenza, Human (prevention & control)</term><term>Male (MeSH)</term><term>Pulmonary Disease, Chronic Obstructive (mortality)</term><term>Seasons (MeSH)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Broncho-pneumopathie chronique obstructive (mortalité)</term><term>Calendrier vaccinal (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (prévention et contrôle)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Méthodes épidémiologiques (MeSH)</term><term>Saisons (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Vaccins antigrippaux (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Broncho-pneumopathie chronique obstructive</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Epidemiologic Methods</term><term>Female</term><term>Humans</term><term>Immunization Schedule</term><term>Male</term><term>Seasons</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Calendrier vaccinal</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Méthodes épidémiologiques</term><term>Saisons</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Although there is a general agreement for the recommendation of the influenza vaccine to persons with chronic obstructive pulmonary disease (COPD), the magnitude of clinical effectiveness and benefit from the annual vaccination is controversial. We assessed the effects of annual influenza vaccination on winter mortality in older adults with COPD.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This prospective cohort study included 1298 Spanish community-dwelling individuals aged 65 years or older with a diagnosis of COPD followed from 1 January 2002 to 30 April 2005. The primary outcome was all-cause death during influenza periods (January-April). Multivariable Cox proportional hazard models adjusted by age, sex and comorbidity were used to evaluate vaccine effectiveness.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Influenza vaccination was associated with a non-statistically significant 16% reduction in winter mortality among vaccinated COPD patients [unadjusted hazard ratio (HR): 0.84; 95% confidence interval (CI): 0.60-1.17]. Multivariable analysis showed that there was an insignificant trend towards a reduced mortality in the vaccinated group considering overall influenza periods 2002-2005 (adjusted HR: 0.76; 95% CI: 0.52-1.06; p=0.098). We estimated that, in the total COPD population, one death was prevented for every 187 annual vaccinations (95% CI: 62 to infinity).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our data suggest benefit from the influenza vaccination and support an annual vaccination strategy for elderly COPD patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17573840</PMID><DateCompleted><Year>2008</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1368-5031</ISSN><JournalIssue CitedMedium="Print"><Volume>62</Volume><Issue>1</Issue><PubDate><Year>2008</Year><Month>Jan</Month></PubDate></JournalIssue><Title>International journal of clinical practice</Title><ISOAbbreviation>Int. J. Clin. Pract.</ISOAbbreviation></Journal><ArticleTitle>Effects of annual influenza vaccination on winter mortality in elderly people with chronic pulmonary disease.</ArticleTitle><Pagination><MedlinePgn>10-7</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although there is a general agreement for the recommendation of the influenza vaccine to persons with chronic obstructive pulmonary disease (COPD), the magnitude of clinical effectiveness and benefit from the annual vaccination is controversial. We assessed the effects of annual influenza vaccination on winter mortality in older adults with COPD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This prospective cohort study included 1298 Spanish community-dwelling individuals aged 65 years or older with a diagnosis of COPD followed from 1 January 2002 to 30 April 2005. The primary outcome was all-cause death during influenza periods (January-April). Multivariable Cox proportional hazard models adjusted by age, sex and comorbidity were used to evaluate vaccine effectiveness.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Influenza vaccination was associated with a non-statistically significant 16% reduction in winter mortality among vaccinated COPD patients [unadjusted hazard ratio (HR): 0.84; 95% confidence interval (CI): 0.60-1.17]. Multivariable analysis showed that there was an insignificant trend towards a reduced mortality in the vaccinated group considering overall influenza periods 2002-2005 (adjusted HR: 0.76; 95% CI: 0.52-1.06; p=0.098). We estimated that, in the total COPD population, one death was prevented for every 187 annual vaccinations (95% CI: 62 to infinity).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data suggest benefit from the influenza vaccination and support an annual vaccination strategy for elderly COPD patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vila-Córcoles</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Primary Care Service of Tarragona-Valls, Institut Català de la Salut, Tarragona, Spain. avila.tarte.ics@gencat.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ochoa</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>de Diego</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Valdivieso</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Herreros</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Bobé</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Alvarez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Juárez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Guinea</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Ansa</LastName><ForeName>X</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Saún</LastName><ForeName>N</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Clin Pract</MedlineTA><NlmUniqueID>9712381</NlmUniqueID><ISSNLinking>1368-5031</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004812" MajorTopicYN="N">Epidemiologic Methods</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007115" MajorTopicYN="N">Immunization Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="Y">Influenza Vaccines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029424" MajorTopicYN="N">Pulmonary Disease, Chronic Obstructive</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="Y">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>6</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>6</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17573840</ArticleId><ArticleId IdType="pii">IJCP1414</ArticleId><ArticleId IdType="doi">10.1111/j.1742-1241.2007.01414.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Alvarez, M" sort="Alvarez, M" uniqKey="Alvarez M" first="M" last="Alvarez">M. Alvarez</name><name sortKey="Ansa, X" sort="Ansa, X" uniqKey="Ansa X" first="X" last="Ansa">X. Ansa</name><name sortKey="Bobe, F" sort="Bobe, F" uniqKey="Bobe F" first="F" last="Bobé">F. Bobé</name><name sortKey="De Diego, C" sort="De Diego, C" uniqKey="De Diego C" first="C" last="De Diego">C. De Diego</name><name sortKey="Guinea, I" sort="Guinea, I" uniqKey="Guinea I" first="I" last="Guinea">I. Guinea</name><name sortKey="Herreros, I" sort="Herreros, I" uniqKey="Herreros I" first="I" last="Herreros">I. Herreros</name><name sortKey="Juarez, M" sort="Juarez, M" uniqKey="Juarez M" first="M" last="Juárez">M. Juárez</name><name sortKey="Ochoa, O" sort="Ochoa, O" uniqKey="Ochoa O" first="O" last="Ochoa">O. Ochoa</name><name sortKey="Saun, N" sort="Saun, N" uniqKey="Saun N" first="N" last="Saún">N. Saún</name><name sortKey="Valdivieso, A" sort="Valdivieso, A" uniqKey="Valdivieso A" first="A" last="Valdivieso">A. Valdivieso</name></noCountry><country name="Espagne"><noRegion><name sortKey="Vila C Rcoles, A" sort="Vila C Rcoles, A" uniqKey="Vila C Rcoles A" first="A" last="Vila-C Rcoles">A. Vila-C Rcoles</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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